Reverse an Overdose

Opioid reversal medications are safe, legal medications that can reverse an opioid overdose, including fentanyl, in minutes. Learn how to use them, and carry them with you.

What are opioid overdose reversal medications?

Opioid overdose reversal medications, such as naloxone and nalmefene are widely available medications, that work by temporarily blocking the effects of opioids in the body. 

Using opioid overdose reversal medications can save a life

Fentanyl is found in everything from fake prescription pills to powdered drugs, and people may not know they’re taking it. This is why it’s so important to keep an opioid overdose reversal medication around.

Even if your kids and their friends don’t use drugs, encourage them to carry an opioid overdose reversal medication.

How to use naloxone nasal spray

If someone is showing signs of an overdose, don't wait. Call 911, and give them naloxone nasal spray.

  1. Peel open the container.

  2. Place the nozzle into the person's nostril.

  3. Press the plunger.

Opioid overdose reversal medications are available without a prescription in all 50 states

Check a retail pharmacy shelf or ask a pharmacist how to get naloxone or nalmefene. To find community health programs near you that distribute free or low-cost naloxone, use the map at or select your location on the NEXT Distro website.

Naloxone Nasal Spray Facts
  • Naloxone will reverse a fentanyl overdose, but because fentanyl is so strong, someone who is overdosing may need more than one naloxone dose. This is why it’s urgent to call 911.

  • If there is no effect 2-3 minutes after administering a dose of naloxone, an additional dose may be necessary.

  • Each device holds one dose.

  • If someone doesn't have opioids in their system, naloxone has no effect. It will not hurt them.

  • Even expired naloxone can save a life. (Source: NEXT Distro)